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However, because of the small number of reported patients and the relatively short duration of reported follow-up, one should probably conclude that the natural history of these melanosis lesions remains unclear
For flights longer than 4 to 6 hours, consider using two gel packs and swapping them if one warms up
Nitric oxide acts as a signal for blood vessels to relax and open up, which allows blood to flow more freely and reduces the pressure against the vessel walls
Long-term safety has not yet been established
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