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Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia

We therefore created novel ovarian tumour cell line models in which GSTP1 expression is stably deleted, to investigate whether differential GSTP1 expression directly influenced chemosensitivity to platinum drugs, and to other drugs routinely used in the treatment of ovarian cancer patients

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E., Ratai, E.-M., & Kanwisher, N

Indeed, in models such as breast cancer, EPA/DHA treatment reduces the phosphorylation levels of kinases such as Akt and ERK, and inhibits the PI3K/Akt signaling pathway, which reduces pro-survival signaling and promotes apoptosis (50, 60)