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It is important to bear in mind that IGF-1 serum concentration is 100-fold greater than insulin, however when bound to IGFBPs its biological activity is modulated and in its free-unbound form presents different effects [99, 157]

The only reason that system of rebates even came to exist was to create enticements so certain manufacturers could persuade pharmacy benefit managers and employee-sponsored health plans to favor their drug over others

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(1999) demonstrated that topical and intraperitoneal application of Thymosin Beta-4 increased re-epithelialization by 42-61% over controls in a rat full-thickness wound model

Additional file 2: Supplementary Figure 2