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Critically, these effects were achieved without food intake suppression, distinguishing MOTS-c from GLP-1 receptor agonists whose primary mechanism involves appetite reduction

(Naltrexone is also used in alcohol use disorder.) But there's currently no other drug on the market that would do what GLP-1 drugs appear to do prevent risk of addiction more generally

They quiet food noise, curb cravings, and make it easier to maintain a calorie deficit

Rheumatologists and dermatologists are encouraged to co-manage GLP-1 RA prescribing in appropriate psoriasis patients, particularly in the context of psoriatic arthritis with metabolic comorbidity, while awaiting the RCT evidence that will definitively establish their role in psoriasis-specific treatment algorithms

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