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Studies suggest that LPCAT3 suppresses ACSL4 in IL-1-stimulated chondrocytes, thereby inhibiting ferroptosis and protecting mitochondria, but in other settings, it may exacerbate ferroptotic lipid remodeling (76)
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Irreversible oxidation of the active-site cysteine of peroxiredoxin to cysteine sulfonic acid for enhanced molecular chaperone activity
The proximity of these two mutations to the putative NADP-binding site of G6PD may contribute to the more severe form of disease (85)
