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Estimated dosage per spray: 1 spray 133mcg 2 sprays 266mcg 4 sprays 532mcg 8 sprays 1064mcg Because nasal absorption is generally lower than injectable administration, higher overall usage amounts are commonly discussed compared with subcutaneous use

In early studies, retatrutide has shown more pronounced weight loss and fat-burning potential compared to what many patients experience on tirzepatide or other dual-agonist medications