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van den Dobbelsteen et al., 1996) and with the subsequent conflicting notion that chemical depletion of GSH was not, however, sufficient to induce the apoptotic process (Ghibelli et al., 1999

Their sublingual tablets dissolve under the tongue and are taken daily rather than weekly

This depletion occurs because acetaminophen metabolism generates a reactive metabolite (NAPQI) that binds glutathione for neutralization and elimination