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Stick to twice-daily use and follow up with a hydrating moisturiser to maintain balance
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[Composition analysis and dominance test of three kinds of raw variety of Gynostemma pentaphyllum]
Alhashemi, 2001
Ironically, a side effect of excessive anticholinesterase treatment is excessive weakness or cholinergic crisis due to excessive stimulation of nicotinic receptors in the muscle end-plate region, resulting in a transient phase of uncontrolled muscle fasciculations due to sustained depolarization, followed by the development of receptor desensitization and a flaccid paralysis
