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Despite this, cyanocobalamin has been increasingly criticised in recent years, due to the following reasons: Toxicity: cyanocobalamin is often claimed to be toxic, as the cyano group form the poison cyanide

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Hence, at least a partial overlap in the underlying pathophysiology and thus potential treatment strategies can be assumed for long COVID, PAIS and ME/CFS

Induction of HO-1 expression in dendritic cells inhibits them maturation and secretion of pro-inflammatory cytokines and promotes regulatory T cell (T reg cell) responses