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2.2.2 Heat stress adaptation of the spermatogenic microenvironment The spermatogenic microenvironment refers to the local cellular and structural niche formed by Sertoli cells, Leydig cells, germ cells, and the bloodtestis barrier, which provides the essential conditions for spermatogenesis, including nutrient support, hormonal signaling, and immune privilege, thereby supporting normal sperm development (Frana et al., 2016)
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Additionally, be aware of potential side effects associated with GLP-1 drugs, such as nausea, vomiting, or hypoglycemia
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IL-21 is also a pleiotropic cytokine (525) important for differentiation of follicular helper T cells that are essential for the germinal centre antibody response (526)
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