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Renal biopsy specimens from DKD patients reveal elevated expression of ferroptosis-associated proteinssuch as acyl-CoA synthetase long-chain family member 4 (ACSL4) and prostaglandin-endoperoxide synthase 2accompanied by marked downregulation of glutathione peroxidase 4 (GPX4), a key suppressor of ferroptosis (127)
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Future research should delve deeper into the interaction between central and peripheral energy metabolism organs, with a focus on appetite regulation as an entry point, to further explore the neural circuits in acupuncture studies
10.1016/j.freeradbiomed.2018.08.014 57 RusetskayaN
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