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In this context, Once monthly pipeline remains in clinical trials, pivotal efficacy data is lacking at this stage

For daily antidepressants at steady state, this typically has no clinically meaningful impact on efficacy

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Conclusion GLP-1RAs show significant promise as a potential disease-modifying therapy for neurodegenerative and inflammatory eye diseases, acting through both systemic metabolic improvements and direct ocular mechanisms, representing a paradigm shift beyond their metabolic indications

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