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Extracts of bitter melon also induce modulation of natural killer cells and Treg cells to inhibit proliferation of tumor cells [20, 21]

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Food and Drug Administration,2018)

These encompass the optimization of the dosage and administration regimen of therapeutic agents, the enhancement of tumor models to more accurately mimic the human tumor microenvironment, the indepth elucidation of the mechanism of ICD for the development of novel NDDSs, and the resolution of issues related to the quality control and largescale production of NDDSs