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A recent meta-analysis of 11 cardiovascular outcome trials involving 55,921 patients treated with GLP-1 RAs and 43,306 patients treated with DPP-4 inhibitors also revealed no significant association between either drug class and pancreatic cancer risk

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Incretin therapies The first generation of weight-loss medications are incretin therapies that regulate insulin secretion, building on type 2 diabetes mellitus (T2DM) treatments utilising glucagon-like peptide-1 (GLP-1) receptor agonists