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* Correspondence: Jian-Sheng Zhu, [email protected]

The higher pH protects the peptide from pepsin degradation, which requires acidic conditions

Insulin-like growth factor binding protein-3 mediates hyperosmolar stress-induced mitophagy through the mechanistic target of rapamycin

Some patients report mood changes whilst taking GLP-1 medications, and common side effects such as nausea may increase anxiety in susceptible individuals

Focus on: Protein-rich foods to preserve lean muscle mass during weight loss Iron-containing foods (red meat, leafy greens, fortified cereals) to prevent anaemia, particularly if periods become heavier Calcium and vitamin D for bone health, as oestrogen fluctuations can affect bone density Healthy fats including omega-3 fatty acids, which support hormone production For women using hormonal contraception , the Faculty of Sexual and Reproductive Healthcare (FSRH) advises that semaglutide and liraglutide do not reduce hormonal contraceptive efficacy