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This has potential to alleviate supply shortages currently plaguing the class, and may provide an opportunity for Lilly to bring a lower-cost option to market, though Lillys pricing strategy for orforglipron is unknown and likely to be dependent upon clinical results
Summary: Researchers unmasked an alternative biological pathway explaining how GLP-1 receptor agonist medications alleviate psychiatric symptoms
The lack of activity of the 30 highlights the importance of covalent reactivity in the observed potency in 29
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