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Factor in cardiovascular considerations
[8] [9] As a precautionary measure, consistent with SmPC guidance for the drug class, retatrutide would be expected to be contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN2) Patients who are pregnant, breastfeeding, or planning pregnancy should not use retatrutide, consistent with guidance applicable to other agents in this class
"If absorption of blood thinners is negatively impacted, clots may form in the blood, putting these patients at higher risk of deep vein thrombosis (blood clot in a deep vein, usually in the leg or calf), pulmonary embolism (blood clot in an artery of the lungs), heart attack and stroke," she cautions
Nature (1996) 379:6972
A change that keeps returning, or one linked to high glucose readings, deserves more attention than a one-off change after certain foods or temporary dehydration
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