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Semaglutide (Ozempic/Wegovy): First-line option, acts on 1 receptor (GLP-1) Tirzepatide (Mounjaro): Second-line, acts on 2 receptors (GLP-1 + GIP), effective for patients tolerant to higher semaglutide doses Retatrutide: Most advanced, acts on 3 receptors (GLP-1 + GIP + GCGR), typically reserved for patients who have developed tolerance to tirzepatide Category: Weight Loss Related Products Medication Features Once-weekly injection Weight loss injection by Eli Lilly Active ingredient: Tirzepatide Trials show ~20% body weight loss Available equivalent: Wegovy Mounjaro is a once-weekly weight loss injection containing Tirzepatide and is now licensed for weight loss in the UK