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( 2 O 2 , a potent ROS-inducer, and superoxide dismutase (SOD), a natural antioxidant agent, were higher in GO then control OFs, whereas the ROS antagonist glutathione peroxidase (GPX) was reduced, with a reduced ratio between glutathione and oxidized glutathione, suggesting the presence of a remarkable state of oxidative stress ( Glycosaminoglycan Production and Heat Shock Protein 72 Expression in Orbital fibroblasts As mentioned above, the release of GAGs plays an important role in the pathogenesis of GO
Genetic and Biomarker Context for Individual Risk Genetic variations in GLP1R (glucagon-like peptide-1 receptor) and GIPR (glucose-dependent insulinotropic polypeptide receptor) genes influence how your cells respond to these medications and may correlate with gastrointestinal side effect susceptibility
The primary outcome was progression by 3 or more steps on the ETDRS scale at study endpoint
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