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This improvement in glycaemic control occurs alongside reductions in both fasting and post-prandial (after-meal) glucose levels
The first study to demonstrate superiority over placebo was the LEADER study, in which 9,340 patients were assigned to either liraglutide or placebo
This thermogenic component is why retatrutide research outcomes in obesity models have exceeded those of tirzepatide in comparative literature, with 48-week weight reduction data reaching 24.2% for retatrutide against tirzepatides published benchmarks from SURPASS trials
I encourage people to focus on consistency rather than trends
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