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In a head-to-head trial against semaglutide (the SURPASS-2 trial), tirzepatide produced significantly greater weight loss, with participants taking the highest dose of tirzepatide losing an average of 11.2 kg (24.7 lbs), compared to 5.7 kg (12.5 lbs) for those taking semaglutide 1 mg
Somatic-specific RNAi knockdown of either stim-1 or orai-1 from early larval development causes sterility in adults, suggesting a non-cell-autonomous effect on germline development 58,59
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It means that sustainable results require either long-term medication use or significant lifestyle changes during treatment that persist after stopping
