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Lactic acidosis reports were markedly lower with combination therapy (567 vs 15,789), as were acute kidney injury (675 vs 7,694), diarrhoea (3,890 vs 6,922), and metabolic acidosis (203 vs 4,713), suggesting that the addition of GLP-1 RAs to metformin may mitigate serious adverse effects associated with metformin alone (Table 2)

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Coordination of smooth muscle activity is dependent upon the enteric neural plexus, especially the myenteric plexus, and the intensity of contraction depends upon the sympathetic and parasympathetic efferent neural activity

In July, Britain urged clinicians to prescribe only Ozempic and six other medicines from the GLP-1 class for their licensed uses, not for weight loss

In the gastrointestinal tract, GLP-1 binding to its receptors delays gastric emptying, reduce appetite, and increase satiety [11]