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N Engl J Med 391(2):109121 De Nicola L, Cozzolino M, Genovesi S et al (2022) Can SGLT2 inhibitors answer unmet therapeutic needs in chronic kidney disease

GLP-1 drugs like Wegovy, Ozempic, Trulicity, and more are generating a lot of buzz for their effectiveness in weight loss and diabetes management

And you cannot stop the friendly fire until you close the gates in the castle wall

Risks of Improper Peptide Use Long-Term Overstimulation Concerns Chronic elevation of growth-related pathways, particularly without cycling, may contribute to unwanted effects such as: Hormonal imbalance Reduced receptor sensitivity Potential tissue overgrowth Increased cardiovascular strain Maintaining physiological balance is essential

The 4mg dose may serve as a maintenance dose after initial weight loss on higher doses