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If GLP-1 drugs can help someone lose weight and move them past leptin resistance, its possible leptin used in conjunction with them could lead to longer-lasting or more effective weight loss

Semaglutide is FDA-approved for multiple indications: as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus

the effects typically last for a few hours, so planning ahead can help you make the most of your treatment