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Nature (2011) 472:5763
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Incretin agonist clinical trials most frequently reveal nausea as an adverse effect
PKA and EPAC signals via Gs activation partly increase GLP-1 secretion in GLUTag cells and insulin secretion in GLP-1R-MIN-6 cells
Convergence with Combination Biology Dual and multi-agonist molecules combining GLP-1 activity with GIP and/or glucagon receptor activity are emerging and driving superior metabolic efficacy in clinical studies
