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Cascade-responsive systems are designed to undergo stepwise structural changes as they transit from circulation through the tumor microenvironment into cancer cells, with each stage triggered by a distinct stimulus [178, 179]
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Encapsulation of 16-hydroxycleroda-3,13-dine-16,15-olide in mesoporous silica nanoparticles as a natural Dipeptidyl peptidase-4 inhibitor potentiated hypoglycemia in diabetic mice
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