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Prescribing an unapproved new drug outside a trial is technically illegal under the FDCA (aside from narrow compassionate-use exceptions)
In contrast, our results indicated that exogenous MOTS-c counteracts oxidative stress by activating the Keap1-Nrf2 signaling pathway, which is similar to the effect of exercise to activate the Keap1-Nrf2 signaling pathway 64
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These networks orchestrate a wide array of resistance-enabling processes, including survival signaling, cell fate plasticity, immune evasion, metabolic rewiring, DNA repair, and maintenance of cancer stemness
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