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Because of their already highly sensitized bodies and a low threshold of stimulatory excitation response, any product including methylated folate or methylated B12 can further increase an excitation response and trigger an adrenal crash

Sugiya, (2012), Oxidative Stress Environmental Induction and Dietary Antioxidants, Edited by Volodymyr I

The xenobiotic adaptation in arthropods evolves through multiple mechanisms (Figure 1) [13, 14], including reduced penetration through the cuticle, behavioral avoidance [15, 16], microbiome-mediated detoxification [17-20], enhanced metabolic detoxification [21-25], enhanced sequestration or excretion [13, 19, 26, 27], and target site insensitivity [28-32]

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According to The Ordinary, the formula boasts a technology called REDENSYL complex