During the chronic phase, the goal is to increase the metabolic capacity of surviving networks and enable rehabilitation-driven plasticity [29, 41,42,43]
The difference between the effects of both QIs on the cell viability ( Figure 2 ) and caspase 3 activation ( Figure 4 ) suggests that upon GSH depletion, the decrease in cell viability is not only apoptosis dependent but also most likely depends other cell death pathways, such as necrosis ( IC 50 values of QIs under GSH-depleted conditions were around 20 M ( Figure 2 ), which is higher than the plasma concentrations of AQ and DEAQ found in patients, normally in nanomolar to micromolar ranges (Laurent et al., 1993
Efectos secundarios Nuseas Vmitos Diarrea Dolor abdominal Estreimiento Acidez Eructos (gases) Pancreatitis Enfermedad de la vescula biliar Lesin renal aguda Reacciones de hipersensibilidad (alergias graves) Complicaciones de la retinopata diabtica Obstruccin intestinal Gastroparesia grave Algunos de estos efectos secundarios son leves y transitorios, como la nusea o el dolor abdominal
Graves BS, Patel M, Newgent H, Parvathy G, Nasri A, Moxam J, et al
That question resolves most cases on the spot, and no further work-up is needed
