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Importantly, the UPR does not function as a unidirectional survival pathway
however, the reversal potential of GABA A R-mediated post-synaptic current in dentate gyrus granule cells is positive to the resting membrane potential, making membrane hyperpolarization of GABA A Rs unlikely in this region
One of the most common physiological changes seen is the depletion of the bodys most powerful antioxidant, reduced glutathione
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