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Oral administration of myricetin significantly reduces Fe 2+ levels in the substantia nigra of PD rats, inhibits neuronal ferroptosis, decreases ROS production, downregulates malondialdehyde (MDA) and -synuclein (-Syn) expression, elevates GSH levels, and ameliorates motor deficits
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Unlike other compounds that act through vascular pathways, PT141 acts directly on the central nervous system , making it a unique agent in neurobehavioral and sexual health research
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