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The ZDHHC7 palmitoylates NLRP3 on Cys126, and thus mutation of NLRP3 Cys126 would disrupt its localization in the TGN as well as the recruitment and oligomerization of ASCs, inhibiting the activation of the inflammasome (71) ( Figure 3 )
This makes the risk of side effects very low
As a result, various members of the family were found overexpressed in a number of different cancers
doi: 10.1016/j.jacc.2005.09.050 104 LiC-jLvLLiHYuD-m
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