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Oxidative stress occurs when reactive oxygen species exceed the bodys ability to regulate them through antioxidant systems
doi:10.1146/annurev.me.27.020176.002115
It is not legally marketed as a medicine in the United States, and regulatory agencies in several countries have issued public warnings specifically against its use
Phase IIIII clinical trials are evaluating checkpoint blockade in combination with TGF- pathway inhibitors or antiangiogenic agents to normalize the vasculature and relieve T-cell exclusion
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