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Intravenous administration results in even more rapid excretion with little opportunity for liver storage

Safety and Tolerability Jones, P

A seminal cost analysis published in Canadian Family Physician (2001) projected that switching patients from intramuscular B12 injections to oral supplements could save between $2.9 million and $17.6 million depending on the population studied with one Ontario analysis estimating $14.5 million in savings for 110,000 elderly patients

These two cover the majority of the human bodys B12 needs

A 2010 study also found kidney function declined much quicker in one form of kidney disease in those who supplemented B12 compared to no supplementation.[2] It is difficult to 100% confirm all forms used in these studies were cyanocobalamin, but the ones that did mention the type of B12, did use cyanocobalamin and this is often the most commonly supplemented form