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Deacon CF, Nauck MA, Toft-Nielsen M, Pridal L, Willms B, Holst JJ
PMCID: PMC12109301
Clinically, the ATTAIN Phase 3 program showed that orforglipron at its highest dose delivered a mean weight loss of 12.4% over 72 weeks, slightly less than the WEGOVY pills 13.6% at 64 weeks, but with a broader, more diverse patient population of over 3,000 participants
When Cold-Turkey Cessation Is Medically Contraindicated Abrupt GLP-1 discontinuation is contraindicated in patients with uncontrolled diabetes, recent weight loss, or ongoing metabolic instability
Designated a California Historical Landmark , it also holds global significance as the site where the United Nations Charter was signed in 1945
