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Avoid administering liraglutide concurrently with other anti-diabetic medications, such as insulin, due to an increased risk of hypoglycemia
Women of childbearing potential must comply with the MHRA Pregnancy Prevention Programme for topiramate, using highly effective contraception and signing risk acknowledgement forms
Newer tools such as CRISPR/Cas-based genome editing, promoter engineering and inducible expression systems offer opportunities to fine-tune spermidine accumulation in selected organs (e.g., edible tissues) or under specific stress conditions
Avoid heat
Understanding how these two substances work independently is essential before considering their combined use
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