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Conformational changes that correspond to the binding of PrP with Cu 2+ are associated with prion disease, and these are usually induced by alterations to Cu 2+ -to-histidine occupancy within the PrP molecule
Further, 12 of them have been recognized as putative drug transporters, including well-known P-gp encoded by the ABCB1 gene, MDR-associated protein 1 (MRP1, encoded by the ABCC1 gene), and ABC subfamily G member2, also known as breast cancer resistance protein, which is encoded by the ABCG2 gene [78, 79]
Amino acids, NAC (N-acetyl L-cysteine) and l-carnitine complete the complex
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