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Co-administration of HIF inhibitors with immune checkpoint blockade (e.g., anti-PD-1/PD-L1), angiogenesis inhibitors (e.g., bevacizumab), or metabolic modulators (e.g., glutaminase inhibitors) may produce synergistic antitumor responses
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3.4.6 TAM family of receptor tyrosine kinases The increase in CORT induced by stress also activates the GR-MERTK signaling pathway in astrocytes, leading to heightened phagocytosis of excitatory synapses by astrocytes in cortical regions, thereby eliciting depressive behavior in mice (255)
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