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What it is / mechanism 5-Amino-1MQ is a selective, cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide (consuming the methyl donor SAM) to form 1-methylnicotinamide, diverting nicotinamide away from the NAD+ salvage pathway

As no medications are available to treat G6PD deficiency, here we seek to identify a small molecule that corrects it

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Stroke (2017)

its benefits persist only with continued use, similar to how antihypertensive medication only controls blood pressure while it is being taken