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So, in summary: FOXO4-DRI appears to represent the next-generation senolytic, offering improved specificity, but it is still earlier stage than many small-molecule senolytics or repurposed drug combinations
These considerations play a significant role in supporting research integrity and maintaining established scientific standards
PER1 affects cancer growth and causes an increased rate of ionizing radiation-induced cell death, but it is unclear whether its lack of expression precedes and contributes to cancer development, or is the only source of cancer
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