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SURMOUNT-1
The MC1R gene is among the most polymorphic in the human genome and with numerous loss-of-function variants associated with red hair, fair skin, increased UV sensitivity, and elevated melanoma risk , and MT-1 is used as a research tool for studying how MC1R polymorphisms influence receptor function, signalling capacity, and downstream melanogenesis and photoprotection biology
Human clinical data remains limited in volume, though the existing studies are encouraging
The sequencing data were aligned to the mm10 (GRCm38) transcriptome, obtained from the Ensembl database, using STAR v.2.7.3a
The GRADE trial provides some insights, reporting a cardiovascular benefit with liraglutide
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