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First, greater total weight loss (28.7% vs 22.5%)
doi: 10.1073/pnas.1606786113
Overall, this resulted in a 53% reduction in integrated incremental GLP-1 concentrations (AUC above baseline) in type 2 diabetic patients relative to healthy controls and a 19% reduction in the total AUC (above 0 pmol/l)
The company continues evaluating expansion opportunities as regulatory landscapes evolve and as provider networks grow
Because 14 mg is the maximum labeled dose, off-label weight-loss protocols may attempt higher exposure by frequency, but that raises safety and tolerability concerns
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