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APAP patients showed dramatic increase in some miRNAs (miR-122-5p, miR-27b-3p, miR-21-5p, miR-125b-5p, miR-194-5p, miR-193a-5p and miR-1290) before the ALT elevations above 1000 IU/L
10.1002/ejhf.240 77 SaponaroF.SonaglioniA.RossiA.MontefuscoL.LombardoM.AddaG.et al (2016)
The MSNs-ss-SA treatment resulted in the highest lignin content increase (1.73-fold) among all treatments, likely due to the synergistic release of active components such as SA and bioavailable silicon, which substantially activated lignin biosynthesis pathways in rice plants [83, 84]
A majority of the elevated miRNAs showed recovery with NAC treatment, but miR-1290 remained elevated for at least 2 days
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