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The peptide also demonstrates protection against corticosteroid-induced tendon damage, which is particularly relevant for athletes who have received steroid injections

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& Tekutyeva, L

When the hydrophobic component was mixed with water, the large positive enthalpy of mixing could result in a miscibility gap at a wide range of mixing ratios, consistent with the hydrophobic properties of these compounds

Phase 3 monotherapy available Feature Expected GI burden Cagrilintide + Retatrutide Very high CagriSema (Cag + Sema) High Retatrutide Alone High Feature Dysesthesia risk Cagrilintide + Retatrutide Yes (retatrutide component) CagriSema (Cag + Sema) No Retatrutide Alone Yes Feature Injections per week Cagrilintide + Retatrutide 2 (separate) or 1 (pre-blend) CagriSema (Cag + Sema) 1 or 2 Retatrutide Alone 1 Feature Regulatory status Cagrilintide + Retatrutide Neither approved