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FOXO4-DRI is a synthetic D-retro-inverso peptide studied as a senolytic, meaning it is designed to selectively clear senescent cells
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the authors reported a significant reduction in all-cause mortality (p=0.009) in the group of transplant recipients receiving steroids, treated with GLP-1 RAs, indicating a 38% lower risk of death compared to nonusers (55)
In terms of GI effects, it can cause gas, (sometimes with discharge), urgent or increased bowel movements, oily or fatty stools, loose stools, discolored stool, nausea, vomiting, diarrhea, and rectal and stomach pain
Bansal R, Khan R, Grover SC (2025) Measuring the quality and safety of upper endoscopy in patients taking glucagon-like peptide 1 receptor agonists
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