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Mol Reprod Dev 49 : 343355 Whitin JC, Tham DM, Bhamre S, Ornt DB, Scandling JD, Tune BM, Salvatierra O, Avissar N, Cohen HJ 1998 Plasma glutathione peroxidase and its relationship to renal proximal tubule function

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Glutathione is synthesized in a two-step process, in which the first and rate-limiting enzyme -glutamylcysteine synthetase (ECS or GSH1) converts glutamate and cysteine to EC, then glutathione synthetase (GSH2) forms glutathione by the ligation of an additional glycine to the intermediate 42,43 (Fig