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Male mice underwent rapid loss of survival at extended time points, while female mice were largely unaffected
Most are peptides, but some are not
Glutathione can work almost immediately in reducing symptoms of brain fog that can occur post-illness or intense competition when delivered intravenously
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Keywords : Methotrexate, oral ulceration, mucositis, DMARD, pancytopenia, rheumatoid arthritis Abbreviations MTX: methotrexate MIOM: methotrexate-induced oral mucositis DMARDs: disease-modifying anti-rheumatic drugs RA: rheumatoid arthritis LDMTX: low-dose methotrexate ADR: adverse drug reaction UPOHC: University of Pretoria Oral Health Centre FBC: full blood count RCC: red cell count Hb: haemoglobin MCV: mean corpuscular volume MCH: mean corpuscular haemoglobin MCHC: mean corpuscular haemoglobin concentration GERD: gastroesophageal reflux disease eGFR: estimated glomerular filtration rate DHFR: dihydrofolate reductase DHF: dihydrofolate THF: tetrahydrofolate TS: thymidylate synthase AICART: aminoimidazole carboxamide ribonucleotide transformylase RFC1: reduced folate carrier 1 MTX-PG: methotrexate-polyglutamate PPI: proton pump inhibitor INTRODUCTION Methotrexate (MTX) was originally developed to treat malignant diseases
