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While it is not clear how this translates to the kinetics of cAMP production in cells expressing individual receptors, the divergence in peptide responses across each receptor is consistent with the dynamic conformational differences that were observed structurally for individual AMYRs bound to distinct peptides

DOI: 10.1016/S0140-6736(21)00845-X

The documented pattern is simply a steady daily presence of the inhibitor, held long enough for the downstream metabolic change to accumulate