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EGFR-mutant NSCLC may undergo histological transformation into small cell lung cancer (SCLC) under TKI pressure, which is inherently resistant to EGFR-targeted therapy

Accessed May 26, 2026.

Diabetes and cardiovascular/sleep apnea indications are covered separately

Table 2 lists previous studies about the effects of these treatments in the pediatric population

198 Several pathways have been implicated in micropinocytosis events, such as the ERK/MAPK pathway activated by oncogenic RAS, and PI3K/mTOR signalling pathways