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DRUG INTERACTIONS As with other medications, zonisamide can interact with certain medications, including carbonic anhydrase inhibitors (such as acetazolamide), orlistat (if using zonisamide for a seizure disorder), phenobarbital, primidone, rifamycins, glucocorticoids, and St
PMCID: PMC9037278
Many patients start to notice changes in their appetite and eating habits within the first few weeks, but significant weight loss typically begins after about a month of treatment
( a , b ) Weight (a), and fasting and fed glycaemia (b) of lean adult beta cell-selective -arrestin 2 (-Barr2) KO vs control male and female mice (n = 6-9 / genotype and sex, age: 20-24 weeks)